ATP2B4/A0114

Plasma membrane calcium-transporting ATPase 4 (ATP2B4), also known as A0114, is a multi-pass membrane protein, which catalyzes the hydrolysis of adenosine triphosphate (ATP) coupled with the transport of calcium out of the cell.

Plasma membrane calcium-transporting ATPase 4 (ATP2B4), also known as A0114, is a multi-pass membrane protein, which catalyzes the hydrolysis of adenosine triphosphate (ATP) coupled with the transport of calcium out of the cell. ATP2B4 requires magnesium for its function. Alternative splicing produces eight isoforms of this protein. Of those, the isoform XB is ubiquitously expressed while others have a more restricted expression. ATP2B4 null male mice are infertile because their sperm does not achieve hyperactivated motility, which is needed to traverse the female genital tract. ATP2B4 -/- animals suggest that expression of this transporter in the principal piece of the sperm tail is necessary for hyperactivated motility and male fertility.