GluR6

Synaptic-Associated protein 97 (SAP97) is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD-95, SAP102, SAP97, PSD-93).

Synaptic-Associated protein 97 (SAP97) is a scaffold protein that belongs to the membrane-associated guanylate kinase (MAGUK) family (PSD-95, SAP102, SAP97, PSD-93). SAP97 is expressed in different tissues during embryo development and widely expressed in adult mice. SAP97 is localized in the basolateral membrane of polarized cells. In brain, is mainly expressed in cerebellum, cerebral cortex, hippocampus and olfactory bulb. Alternative splicing produces 3 different isoforms. The predicted 905 amino acid sequence contains three PDZ domains, a SH3 domain, a guanylate kinase-homology (GK) domain and a L27 domain that interact with receptors, potassium channels, associated signalling proteins and cytoeskeletal proteins. Overexpression of SAP97 in embryonic primary neurons increases the amount of AMPA receptors on surface, the spine enlargement and an increase in miniature excitatory postsynaptic current (mEPSC). SAP97 knock-out mice have craniofacial abnormalities, small kidneys, shorten ureters, reduced nephron formation and die few hours after birth.