AKT2/A0466

AKT2, also known as A0466, belongs to the AGC group of serine/threonine kinases and the AKT family, which together with the other family members (AKT1 and AKT3) are involved in the transduction of the phosphoinositide signal transduction cascade.

AKT2, also known as A0466, belongs to the AGC group of serine/threonine kinases and the AKT family, which together with the other family members (AKT1 and AKT3) are involved in the transduction of the phosphoinositide signal transduction cascade. The expression of the AKT2 gene is enriched in insulin-responsive tissues. Mice deficient in AKT2 expression present mild growth deficiency, defects in the insulin receptor signaling pathway, insulin resistance and severe defects in glucose metabolism. Mutations in the human AKT2 gene are associated with severe insulin resistance and diabetes.