PKCγ/A0259

Protein kinase C gamma (PKCγ), also known as A0259, is one of the isoforms of protein serine/threonine kinase C (PKC).

Protein kinase C gamma (PKCγ), also known as A0259, is one of the isoforms of protein serine/threonine kinase C (PKC). At least 10 isoforms have been described. PKC belongs to the AGC group of protein kinases. The different isoforms are classified according to their activation requirements. The classical or conventional isoforms, (cPKC) include PKCα, βI, βII and γ, and are regulated by calcium and diacylglycerol (DAG). The novel PKCs (nPKC), PKCδ, ε, η and θ are activated by DAG but calcium independent. The atypical isoforms (aPKC), PKCζ and λ/ι) are regulated by DAG/ phorbol ester and are calcium insensitive. Different mutations in the PRKCG gene are associated with spinocerebellar ataxia type 14 and the PRKCG locus has been linked with behavioral disinhibition. PKCγ mutant mice exhibit mild deficits in spatial and contextual learning. It is reported that PKCγ binds and modulates GluR4-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function.