RAF1/A0138

RAF1, also known as A0138, is a member of the serine/threonine kinase family and is referred to as mitogen-activated protein (MAP) kinase kinase kinase.

RAF1, also known as A0138, is a member of the serine/threonine kinase family and is referred to as mitogen-activated protein (MAP) kinase kinase kinase. It is a member of the post-synaptic proteome and N-methyl-D-aspartate (NMDA) receptor complex synaptic proteomes, in both humans and mice. Functioning further downstream of the membrane-associated Ras GTPases, it binds directly to, and phosphorylates, MEK1 and MEK2, which then activate extracellular signal-regulated kinase 1 (ERK1) and ERK2, in a similar fashion. RAF1 is encoded by a gene found on chromosome 6 and a translocation mutation in this gene has been found to lead to Gilles De La Tourette syndrome. Mutations in the gene have also been associated with Noonan syndrome 5 and Leopard syndrome 2.