AKAP5/A0143

AKAP5 (A-kinase anchor protein), also known as A0143, is an important post-synaptic scaffold protein that binds different signaling proteins such as the protein kinase A (PKA) regulatory subunit type II (PKA-RII), calcium-dependent phosphatase ...

AKAP5 (A-kinase anchor protein), also known as A0143, is an important post-synaptic scaffold protein that binds different signaling proteins such as the protein kinase A (PKA) regulatory subunit type II (PKA-RII), calcium-dependent phosphatase calcineurin (PP2B), and protein kinase C (PKC). AKAP5 determinate the association of this protein with a particular subcellular structure. This transmembrane protein is ubiquitously expressed in the brain. It is crucial for the regulation of several synaptic receptors such as glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA) and the beta2-adrenergic receptor. AKAP5 recruits signaling proteins close its substrate, facilitating the protein interaction so that protein assembles and integrates signals derived from multiple pathways. There are no known mutations of AKAP5 associated with a disease state. However, the mutation of the AKAP150 gene blocks PKA binding, reducing PKA within post-synaptic density structures and abolishing hippocampal long-term potentiation (LTP) in adult mice (7-8 week old). The basal synaptic transmission was normal in these mice. This effect is related to deficiency in the regulation of the AMPA receptor by PKA (MGI).