GAPDH/A0331

GAPDH (glyceraldehyde-3-phosphate dehydrogenase), also known as A0331, is an enzyme that catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate (GAP) in the presence of inorganic phosphate and nicotinamide adenine dinucleotide ..

GAPDH (glyceraldehyde-3-phosphate dehydrogenase), also known as A0331, is an enzyme that catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate (GAP) in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). Although best known as a general housekeeping gene, it is expressed throughout the brain and has been shown to function at the synapse. Acting as a kinase, it phosphorylates the alpha-1 subunit of the gamma-amino butyric acid (GABA)-A receptor, thereby regulating GABA-A receptor physiology. GAPDH binds to the Huntington protein, has been implicated in neuronal apoptosis and some reports have shown an association between single nucleotide polymorphisms (SNPs) in the gene and Alzheimer’s disease. Moreover, significant decreases in GAPDH activity was observed in a mouse model of Alzheimer’s disease.