NO/A0262

Nitric oxide (NO, also known as A0262) is a membrane-permeable signaling molecule, with properties similar to a neurotransmitter in the central and peripheral nervous systems.

Nitric oxide (NO, also known as A0262) is a membrane-permeable signaling molecule, with properties similar to a neurotransmitter in the central and peripheral nervous systems. NO is synthesized from argenine by nitric oxide synthase (nNOS). nNOS is expressed in the central and peripheral nervous systems, as well as other tissues, including skeletal muscle. NOS1 knock-out mice show no gross anatomical impairment, normal long-term potentiation (LTP) and long-term depression (LTD), resistance to stroke damage induced by cerebral artery ligation, and increased aggressive behavior. Inhibiting nNOS (and iNOS) is neuroprotective in Parkinson’s disease. Polymorphisms in NOS1 are associated with susceptibility to schizophrenia and bipolar disorder.