DNM1/A0095

Dynamin 1 (DNM1), also known as A0095, belongs to the family of dynamin, a subfamily of guanosine triphosphate (GTP)-binding and microtubule-binding protein which share considerable sequence homology in their N-terminal domains but more limited ...

Dynamin 1 (DNM1), also known as A0095, belongs to the family of dynamin, a subfamily of guanosine triphosphate (GTP)-binding and microtubule-binding protein which share considerable sequence homology in their N-terminal domains but more limited homology in their C-terminal regions. Mammals have at least 3 dynamin homologs: DNM1, DNM2 and DNM3. DNM1 is involved in microtubule bundling, and it probably plays a role in vesicular trafficking processes. In particular, DNM1 is demonstrated to function in receptor-mediated endocytosis in clathrin-coated vesicle formation. DNM1 is expressed at a similar level in all tissues examined, but in the brain its expression is at least 30-fold higher. Targeted knock-out of DNM1 give viable mice that survive until 2 weeks of age. The mice have poor motor coordination, probably due to impaired synaptic vesicle endocytosis. It is concluded that dynamin-1 is not required for embryonic development or for the neurotransmission, but is needed during high levels of neuronal activity.