PP2A/A0132

The serine/threonine protein phosphatase 2A catalytic subunit alpha (PP2A, also known as A0132), is an isoform of the catalytic subunit of the serine/threonine phosphatase (PP2) and belongs to the PPP family of protein phosphatases, PP1 subfamily.

The serine/threonine protein phosphatase 2A catalytic subunit alpha (PP2A, also known as A0132), is an isoform of the catalytic subunit of the serine/threonine phosphatase (PP2) and belongs to the PPP family of protein phosphatases, PP1 subfamily. As with other members of this family, PP2A associates with a variety of regulatory subunits. The regulatory subunit interacts with the core phosphatase dimmer, composed of a catalytic subunit and a constant regulatory subunit. PP2A has been implicated in the modulation of different metabolic pathways, as translation, cell growth and transcription. However PP2A is different to other PP2 phosphatases in that its activity is not regulated by metal ions. Homozygous null mutant mice are embryonically lethal.