Neurofibrillary Tangles - Hallmark of Alzheimer's Disease

Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.

Neurofibrillary tangles are the other classic histopathological hallmark of Alzheimer’s disease. [They] are an intracellular lesion based on aberrant phosphorylation of the Tau protein that lead to sort of an accumulation of Tau, known as a tangle, inside the cell, ultimately leading to death of those neurons.